Journal: Scientific Reports

Article Title: Effects of anti-epileptic drugs on spreading depolarization-induced epileptiform activity in mouse hippocampal slices

doi: 10.1038/s41598-017-12346-y

Figure Lengend Snippet: Clinical and in vitro doses for AEDs.

Article Snippet: Carbamazepine, valproate, lamotrigine, zonisamide, felbamate, gabapentin, and vigabatrin were obtained from Tocris (Avonmouth, Bristol, UK).

Techniques: In Vitro, Concentration Assay, Cell Culture

Journal: Scientific Reports

Article Title: Effects of anti-epileptic drugs on spreading depolarization-induced epileptiform activity in mouse hippocampal slices

doi: 10.1038/s41598-017-12346-y

Figure Lengend Snippet: Effects of AEDs on parameters of SD.

Article Snippet: Carbamazepine, valproate, lamotrigine, zonisamide, felbamate, gabapentin, and vigabatrin were obtained from Tocris (Avonmouth, Bristol, UK).

Techniques: Control

Journal: Scientific Reports

Article Title: Effects of anti-epileptic drugs on spreading depolarization-induced epileptiform activity in mouse hippocampal slices

doi: 10.1038/s41598-017-12346-y

Figure Lengend Snippet: The effects of lamotrigine, zonisamide, and felbamate on SD-induced epileptiform activity. ( A ) Representative traces showing the changes in the membrane potential after treatment with lamotrigine (60 μM) and zonisamide (50 μM) or felbamate (100 μM). ( B ) Quantitative results showing the effects of AEDs on the duration of ictal-like activity. ( C ) Quantitative results showing the frequency of PDSs after treatment with lamotrigine (60 μM) and zonisamide (50 μM), or felbamate (100 μM) compared to that of control. ( D ) Quantitative results showing the number of spikes per PDS after treatment with lamotrigine (60 μM) and zonisamide (50 μM) or felbamate (100 μM) compared to control. Significance differences were determined by a One-way ANOVA with the Games-Howell post hoc test and were defined as *P < 0.05; **P < 0.01; ***P < 0.001.

Article Snippet: Carbamazepine, valproate, lamotrigine, zonisamide, felbamate, gabapentin, and vigabatrin were obtained from Tocris (Avonmouth, Bristol, UK).

Techniques: Activity Assay, Membrane, Control

Journal: Journal of Veterinary Internal Medicine

Article Title: Population pharmacokinetics of extended‐release levetiracetam in epileptic dogs when administered alone, with phenobarbital or zonisamide

doi: 10.1111/jvim.15298

Figure Lengend Snippet: Population model plots of fitted curves for all individual dogs (solid line) with observed data points (open circles) after the addition of treatment as a covariate. (A) LEV‐XR alone; (B) LEV‐XR and phenobarbital; (C) LEV‐XR and zonisamide. Minimum reference range in humans in noted by (‐‐‐‐‐‐)

Article Snippet: For the zonisamide assay, a pure analytical reference standard was obtained from a supplier (Zonisamide reference standard, >99% pure; TOCRIS Biosciences, Bristol, UK, http://www.tocris.com ).

Techniques:

Journal: Journal of Veterinary Internal Medicine

Article Title: Population pharmacokinetics of extended‐release levetiracetam in epileptic dogs when administered alone, with phenobarbital or zonisamide

doi: 10.1111/jvim.15298

Figure Lengend Snippet: Final parameters for the population analysis of levetiracetam concentrations with LEV‐XR administered alone, with phenobarbital, or with zonisamide. Administration of LEV‐XR was repeated every 12 hours to achieve steady‐state conditions before sampling

Article Snippet: For the zonisamide assay, a pure analytical reference standard was obtained from a supplier (Zonisamide reference standard, >99% pure; TOCRIS Biosciences, Bristol, UK, http://www.tocris.com ).

Techniques: Sampling